It has published research showing that most primary teachers believe science has become less of a curriculum priority, with more than a third of schools now providing less than the recommended two hours of science education a week.
In Tomorrow's World, a new report co-authored by Brunel University London, the CBI revealed that 53% of the 260 primary school teachers surveyed believe teaching science has become less of a priority over the past five years.
John Cridland, CBI director-general, said: "Science education in primary schools is being squeezed out, with over half of teachers believing it has become less of a priority with too many schools struggling to teach the recommended two hours every week.
"How can we expect to inspire future generations of scientists and engineers if we don't deliver high-quality and inspiring science lessons at primary school age? If we are not careful, too many children will have lost interest in science before they hit their teens."
He added: "We must also seriously tackle the persistent cultural problem of pigeon-holing boys and girls into certain subjects and career paths. Schools can have a big impact here, influencing not just pupils but also parents.
"The idea that the education system is successfully inspiring the next generation of scientists and engineers is fantasy."
The report also found that over 70% of primary school teachers wanted more support from business. Of those, three-quarters would find it helpful for businesses to offer use of their equipment and facilities. Over 60% would like support from companies in lesson delivery and arranged class visits.