GSK plans to invest £200 million in the UK to support the delivery of the company's new medicines and create a centre for pharmaceutical manufacturing innovation.
Manufacturing sites in Ware, Hertfordshire and Worthing, Sussex will get new equipment. GSK will also establish a new facility dedicated to harnessing innovative technologies with the potential to transform both the way medicines are made and the company's supply chain.
Roger Connor, GSK's president of global manufacturing and supply, said: "The establishment of the Patent Box has transformed how we see the UK as a place to invest. As a result, last year we announced we were building our first new factory in the UK for 40 years. "
The Patent Box enables companies to apply a lower rate of Corporation Tax to profits earned after 1 April, 2013 from its patented inventions and certain other innovations.
Connor added: "The investments announced today are in addition to that and will allow us to harness new technologies that have the potential to deliver a step-change in how we make medicines.
"These new technologies could significantly reduce costs, improve quality and enable the manufacture of medicines in weeks rather than years and I am delighted that we have been able to bring these investments to the UK."
The investments comprise new manufacturing facilities in Ware for inhaler devices, a new bulk sterile building and filling line in Worthing for antibiotic medicine and a new centre for manufacturing innovation, the location of which has yet to be decided.