Carwyn Jones will meet with companies over the next four days that are looking to invest and expand in Wales and will discuss trade and business links with political representatives.
There are more than 250 American owned companies based in Wales, with the United States accounting for almost 40% of all inwards investment projects last year.
As part of the response to Brexit, the Welsh government will also be strengthening its network of trade and investment offices across the US.
Speaking ahead of the visit, Jones said: “Wales has long been a destination of choice for many American businesses and we want to welcome even more in the future. Equally, Welsh businesses have been successful is selling to the United States across a range of sectors and I believe we can do even better in the future.
“In my discussions with American businesses, politicians and diplomats, I will be raising the importance of further developing free trade between our countries and the removal of barriers to make trade between us easier and quicker.
He continued: “We will also be committing additional resources to North America. We need a permanent presence in Canada, and a strengthened network here in the US. That is a priority for me over the next 12 months, as we restructure our activities overseas to take advantage of new economic opportunities.”
